Blend: Heat the oven to 350°F (175°C). Blend the cottage cheese, eggs, Parmesan, Italian seasoning, garlic powder, and salt until completely smooth.
Bake the crust: Spread into a 10 x 12-inch rectangle, about 1/4 inch thick, on oiled parchment. Bake 35 to 40 minutes, until deep golden and dry on top.
Top: Raise the oven to 425°F (220°C). Cool the crust 5 minutes, flip if you like, then add a thin layer of sauce, the mozzarella, and pepperoni.
Finish: Bake 6 to 8 minutes, until bubbling. Rest 2 minutes, slice, and top with basil and red pepper flakes.